Phosphoethanolamine is present in the plasma membrane of animal cells and takes part in the synthesis of phosphatidylethanolamine in the endoplasmic reticulum¹, as well as several stages of cellular metabolism², such as mitochondrial metabolism, acetylcholine synthesis, and hormonal synthesis.
1 - The endoplasmic reticulum, or ergastoplasma, is a unique organelle of eukaryotic cells. Formed from the invagination of the plasma membrane, it consists of a network of flattened and interconnected tubules and vesicles, which communicate with the nuclear membrane (nucleolemma). It was discovered in 1945 by Belgian cytologist Albert Claude.
2. The term "cell metabolism" is used in reference to the set of all chemical reactions occurring in cells. These reactions are responsible for the processes of synthesis and degradation of nutrients in the cell and are the basis of life, allowing the growth and reproduction of cells, maintaining their structures and adapting responses to their environments.
3 - Acetylcholine (ACh) was the first discovered neurotransmitter. It plays an important role both in the central nervous system (CNS) - consisting of the brain and spinal cord - in which it is involved in memory and learning, as in the peripheral nervous system (PNS) - which includes the somatic nervous system and autonomic nervous system. It is an ester of acetic acid and choline, whose action is mediated by nicotinic and muscarinic receptors.
In the 1960s, German physician Hans Alfred Nieper synthesized and patented Calcium-AEP (Ca-AEP). The substance has three different compositions: Ca-AEP (calcium aminoethanolphosphate), Mg-AEP (magnesium aminoethanolphosphate) and Ca-Mg-K-AEP (calcium magnesium potassium aminoethanolphosphate). The three variations have been marketed in several countries for more than 50 years under the name of phosphoethanolamine, in the form of a food supplement for the transport of minerals. It was observed, therefore, that phosphoethanolamine also had activity in the correction of cellular dysfunctions, and that users of the supplements did not develop cancer.
Born in Germany in 1928, Nieper was educated at Johann Gutenberg University and the University of Freiburg (Germany) before graduating in medicine at the University of Hamburg. During his career he served as director for the Department of Medicine at Silbersee Hospital in Hanover and the German Society for Tumor Treatment Medicine.